Comparative Medicine

Report summarizes comparative medicine study findings from University of Pennsylvania

Published in Gene Therapy Weekly, May 20th, 2010

According to a study from the United States, "Routine surveillance of guinea pigs maintained within a barrier facility detected guinea pig adenovirus (GPAdV) in sentinel animals. These guinea pigs served as models of induced hearing loss followed by regeneration of cochlear sensory (hair) cells through transdifferentiation of nonsensory cells by using human adenoviral (hAV) gene therapy."

"To determine whether natural GPAdV infection affected the ability of hAV vectors to transfect inner ear cells, adult male pigmented guinea pigs (n = 7) were enrolled in this study because of their prolonged exposure to GPAdV-seropositive conspecifics. Animals were deafened chemically...

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Source: Gene Therapy Weekly (2010-05-20)

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