Tissue Engineering
Research on tissue engineering detailed by scientists at University of Pittsburgh, Department of Pathology
Published in Gene Therapy Weekly, May 20th, 2010
New research, 'Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin,' is the subject of a report. "The Wnt/beta-catenin pathway is implicated in the pathogenesis of hepatocellular cancer (HCC). We developed a transgenic mouse (TG) in the FVB strain that overexpresses Ser45-mutated-beta-catenin in hepatocytes to study the effects on liver regeneration and cancer," investigators in the United States report.
"In the two independent TG lines adult mice show elevated beta-catenin at hepatocyte membrane with no increase in the Wnt pathway targets cyclin-D1 or glutamine synthetase. However, TG hepatocytes upon culture...
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Source: Gene Therapy Weekly (2010-05-20)
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