Eicosanoids

New findings in eicosanoids described from University of Munich

Published in Gene Therapy Weekly, May 20th, 2010

According to a study from Munich, Germany, "Molecular conjugates comprising targeting ligands hold great promise for site-specific gene delivery to distant tumors and individual organs including the lung. Here we show that prostaglandin I-2 analogues can be used to improve gene transfer efficiency of polyethylenimine (PEI) gene vectors on bronchial and alveolar epithelial cells in vitro and lungs of mice in vivo."

"Prostacyclin (IP1) receptor expression was confirmed in pulmonary epithelial cell lines by western blot. Iloprost (ILO) and treprostinil (TRP), two prostaglandin I-2 analogues, were conjugated to fluorescein-labeled BSA (FLUO-BSA) and compared for IP1...

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Source: Gene Therapy Weekly (2010-05-20)

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