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Transcription Factors

Findings in transcription factors reported from University of North Carolina

Published in Gene Therapy Weekly, May 27th, 2010

According to recent research from the United States, "Postmortem human alcoholic brain has increased expression of proinflammatory cytokines (He and Crews, 2007). Nuclear factor kappa B (NF-kappa B) is a transcription factor known to induce proinflammatory cytokine expression."

"Ethanol exposure increases NF-kappa B-DNA binding in rat brain (Crews et al., 2006) and in brain slice cultures in vitro (Zou and Crews, 2006). Using hippocampal-entorhinal cortex (HEC) brain slice cultures, we explored the effect of ethanol on NF-kappa B-DNA binding, proinflammatory gene expression, and sensitivity to glutamate neurotoxicity. The HEC brain slice cultures are prepared from rats...

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