C Reactive Protein

New findings from University of Alabama, Division of Cardiovascular Disease in the area of C Reactive Protein published

Published in Gene Therapy Weekly, June 10th, 2010

Research findings, 'C-reactive protein-mediated vascular injury requires complement,' are discussed in a new report. "We previously demonstrated that vascular injury-induced neointima formation is exaggerated in human C-reactive protein (CRP) transgenic (CRPtg) compared to nontransgenic (NTG) mice. We now test the hypothesis that complement is required for this effect," researchers in the United States report.

"CRPtg and NTG with a normal complement system versus their counterparts lacking expression of complement component 3 (C3) protein (CRPtg/C3(-/-) and NTG/C3(-/-)) underwent carotid artery ligation. Twenty-eight days later, the injured vessels in CRPtg had thicker...

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Source: Gene Therapy Weekly (2010-06-10)

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