Research on viral genome reported by scientists at University of North Carolina, Gene Therapy Center

Fresh data on viral genome are presented in the report 'Creating a novel origin of replication through modulating DNA-protein interfaces.' According to recent research from the United States, "While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses. Similar to many viral origins of replication, adeno-associated virus (AAV) utilizes a cis-acting origin of replication and a virus specific Replication protein (Rep) to faithfully carry out self-priming replication."

"The mechanisms of AAV DNA...

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