Amino Acids
Studies conducted at Max Delbruck Center for Molecular Medicine on amino acids recently published
Published in Gene Therapy Weekly, June 10th, 2010
New investigation results, 'Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells,' are detailed in a study published in Journal of Immunology. "TCR gene therapy using adoptive transfer of TCR gene-modified T cells is a new strategy for treatment of cancer. One critical prerequisite for TCR gene therapy is sufficient expression of transferred TCRs," investigators in Berlin, Germany report.
"Several strategies to achieve optimal expression were developed, including 'murinization,' which replaces the human TCRalpha and TCRbeta constant regions by their murine counterparts. Using a series of mouse-human...
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Source: Gene Therapy Weekly (2010-06-10)
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