Gene Therapy
New gene therapy study findings recently were published by researchers at University of Dundee
Published in Gene Therapy Weekly, July 1st, 2010
"Mounting evidence suggests that the presence of microscopic P-bodies are not always required for miRNA-mediated gene regulation. Here we have shown that geldanamycin, a well-characterized HSP90 inhibitor, abolishes P-bodies and significantly reduces Argonaute and GW182 protein levels but does not affect the miRNA level and the efficiency of miRNA-mediated gene repression; however, it significantly impairs siRNA loading and the efficacy of exogenous siRNA," wrote M. Johnston and colleagues, University of Dundee.
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Source: Gene Therapy Weekly (2010-07-01)
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