Published in Gene Therapy Weekly, September 30th, 2010
To prove this novel conclusion, the research team used gene therapy to inhibit the small protein, kinase known as G protein-coupled receptor kinase 2 (GRK2), and found heart muscles cells in mice were substantially protected against destruction that would otherwise occur after an induced myocardial infarction (MI), or heart attack.
Conversely, mice engineered to express excess GRK2 had more damage than would have been expected after an MI, the...
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