Glioblastomas
Data on glioblastomas described by researchers at New York Medical College, Department of Neurosurgery
Published in Gene Therapy Weekly, October 14th, 2010
A report, 'Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility,' is newly published data in International Journal of Oncology. "The AKT/mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in glioblastoma multiforme (GBM) oncogenesis due to activation of AKT. We studied two distinct complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), through which mTOR controls cell survival, growth and motility," scientists in the United States report.
"Inhibition of mTOR by rapamycin (RAPA) resulted in time-dependent suppression of S6 ribosomal protein (pS6KSer235/236; mTORC1 substrate) and caused...
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Source: Gene Therapy Weekly (2010-10-14)
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