Phagocytes
Data on phagocytes described by researchers at University of Pennsylvania
Published in Gene Therapy Weekly, October 28th, 2010
A new study, 'An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages,' is now available. "MIP-1beta/CCL4 is a principal regulator of macrophage migration and signals through CCR5. Several protein kinases are linked to CCR5 in macrophages including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2, and members of the MAPK family, but whether and how these kinases regulate macrophage chemotaxis are not known," scientists writing in the Journal of Leukocyte Biology report.
"To define the role of these signaling molecules, we examined the functions and interactions of endogenous...
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Source: Gene Therapy Weekly (2010-10-28)
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