Gene Therapy
New findings reported from Azienda Ospedaliera University, Department of Internal Medicine describe advances in gene therapy
Published in Gene Therapy Weekly, November 11th, 2010
A new study, 'Ribozyme-mediated compensatory induction of menin-oncosuppressor function in primary fibroblasts from MEN1 patients,' is now available. "Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by the occurrence of tumors of parathyroids, neuroendocrine cells of the gastro-enteropancreatic tract and anterior pituitary. MEN1 gene encodes menin-oncosuppressor protein," scientists writing in the journal Cancer Gene Therapy report.
"Loss of heterozygosity at 11q13 is typical of MEN1 tumors. We have analyzed the MEN1 mRNA and menin expression in fibroblasts from normal skin biopsies and from MEN1 patients (two with a frameshift 738del4 (exon...
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Source: Gene Therapy Weekly (2010-11-11)
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