Small Interference RNAs (siRNAs)
Data on small interference RNAs (sirnas) reported by researchers at University of Marburg, Institute of Pharmacology and Toxicology
Published in Gene Therapy Weekly, December 2nd, 2010
2010 DEC 2 -- Fresh data on small interference rnas (sirnas) are presented in the report 'Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.' "cAMP and Ca(2+) are antagonistic intracellular messengers for the regulation of vascular smooth muscle tone; rising levels of Ca(2+) lead to vasoconstriction, whereas an increase of cAMP induces vasodilatation. Here we investigated whether Ca(2+) interferes with cAMP signaling by regulation of phophodiesterases (PDEs) or adenylyl cyclases (ACs)," researchers in Marburg, Germany report.
"We studied regulation of cAMP concentrations by Ca(2+) signals evoked by endogenous purinergic...
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Source: Gene Therapy Weekly (2010-12-02)
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