Gene Therapy
Gene therapy prevents memory problems in mice with Alzheimer's disease
Published in Gene Therapy Weekly, December 16th, 2010
2010 DEC 16 -- Scientists at the Gladstone Institute of Neurological Disease (GIND) in San Francisco have discovered a new strategy to prevent memory deficits in a mouse model of Alzheimer's disease (AD). Humans with AD and mice genetically engineered to simulate the disease have abnormally low levels of an enzyme called EphB2 in memory centers of the brain. Improving EphB2 levels in such mice by gene therapy completely fixed their memory problems. The findings will be published in the November 28 issue of the journal Nature.
In both humans and mice, learning and memory requires effective communication between brain cells called neurons. This communication...
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Source: Gene Therapy Weekly (2010-12-16)
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