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Biochemistry

Researchers from Lund University report on findings in biochemistry

Published in Gene Therapy Weekly, December 23rd, 2010

2010 DEC 23 -- "Galectin-1, beta-galactoside binding lectin involved in immunoregulation and cancer, binds natural and many synthetic multivalent glycoconjugates with an apparent glycoside cluster effect, that is, affinity above and beyond what would be expected from the concentration of the determinant sugar. Here we have analyzed the mechanism of such cluster effects in solution at physiological concentration using a fluorescence anisotropy assay with a novel fluorescent high-affinity galectin-1 binding probe," scientists in Lund, Sweden report.

"The interaction of native dimeric and monomeric mutants of rat and human galectin-1 with mono- and divalent...

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