Cancer Gene Therapy

Studies from University of Massachusetts, Medical Department add new findings in the area of cancer gene therapy

Published in Gene Therapy Weekly, December 23rd, 2010

2010 DEC 23 -- "Src family kinase (SFK) activity is elevated in many cancers, and this activity correlates with aggressive tumor behavior. The alpha 6 beta 4 integrin, which is also associated with a poor prognosis in many tumor types, can stimulate SFK activation; however, the mechanism by which it does so is not known," scientists in the United States report.

"In the current study, we provide novel mechanistic insight into how the alpha 6 beta 4 integrin selectively activates the Src family member Fyn in response to receptor engagement. Both catalytic and noncatalytic functions of SHP2 are required for Fyn activation by alpha 6 beta 4. Specifically, the...

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Source: Gene Therapy Weekly (2010-12-23)

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