Gene Therapy
University of Cincinnati publishes research in gene therapy
Published in Gene Therapy Weekly, December 30th, 2010
2010 DEC 30 -- A new study, 'Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival,' is now available. According to recent research from the United States, "Transplanted mesenchymal stem cells (MSC) release soluble factors that contribute to cardiac repair and vascular regeneration. We hypothesized that overexpression of GATA-4 enhances the MSC secretome, thereby increasing cell survival and promoting postinfarction cardiac angiogenesis."
"MSCs harvested from male rat bone marrow were transduced with GATA-4 (MSC(GATA-4)) using the murine stem cell virus retroviral expression system; control cells...
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Source: Gene Therapy Weekly (2010-12-30)
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