Ovum

New ovum findings from Tel Aviv University published

Published in Gene Therapy Weekly, December 30th, 2010

2010 DEC 30 -- New investigation results, 'Doxorubicin-induced apoptosis in germinal vesicle (GV) oocytes,' are detailed in a study published in Reproductive Toxicology. "Ovarian failure is a-known side-effect observed in women treated for cancer. Doxorubicin (DXR) was found to be detrimental to MII mouse oocytes," investigators in Israel report.

"We aimed at characterizing the effect of DXR on germinal vesicle (GV) oocytes that comprise the majority of oocytes within ovaries encountering chemotherapy. Mouse follicles and oocytes were exposed to DXR in vitro. DXR localization and its possible cellular targets were examined by fluorescence confocal...

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Source: Gene Therapy Weekly (2010-12-30)

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