Germ Cell Cancer
Study data from University of Tsukuba, Institute of Basic Medical Science update knowledge of germ cell cancer
Published in Gene Therapy Weekly, January 13th, 2011
2011 JAN 13 -- Investigators publish new data in the report 'APAF-1 is related to an undifferentiated state in the testicular germ cell tumor pathway.' "Apoptotic protease activating factor-1 (APAF-1) is a key regulator gene of apoptosis, located downstream from p53. Loss of APAF-1 expression is associated with chemorefractory malignant melanoma and neuronal cell differentiation," investigators in Ibaraki, Japan report.
"In order to make clear the function of APAF-1 in the carcinogenesis of germ cell tumors, we evaluated the expression levels of APAF-1 and several apoptosis and differentiation markers by immunohistochemistry in formalin-fixed...
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Source: Gene Therapy Weekly (2011-01-13)
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