Gene Therapy

Investigators at University of Sao Paulo zero in on gene therapy

Published in Gene Therapy Weekly, January 13th, 2011

2011 JAN 13 -- "Myostatin is described as a negative regulator of the skeletal muscle growth. Genetic engineering, in order to produce animals with double the muscle mass and that can transmit the characteristic to future progeny, may be useful," researchers in Sao Paulo, Brazil report.

"In this context, the present study aimed to analyse the feasibility of lentiviral-mediated delivery of short hairpin RNA (shRNA) targeting of myostatin into in vitro produced transgenic bovine embryos. Lentiviral vectors were used to deliver a transgene that expressed green fluorescent protein (GFP) and an shRNA that targeted myostatin. Vector efficiency was verified...

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Source: Gene Therapy Weekly (2011-01-13)

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