Gene Therapy

Investigators at University of Strasbourg zero in on gene therapy

Published in Gene Therapy Weekly, January 13th, 2011

2011 JAN 13 -- According to recent research published in the journal Bioconjugate Chemistry, "The success in gene therapy relies strongly on new efficient gene delivery vectors. Nonviral vectors based on lipids and polymers constitute an important alternative to the viral vectors."

"However, the key problem with these vectors is the poor structural control of their DNA complexes. In the present work, following new design we synthesized unsymmetrical bolaamphiphiles, molecules bearing neutral sugar (gluconic acid) and dicationic ornithine head groups connected by different long hydrophobic spacers. Within this design, a positively charged headgroup is...

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Source: Gene Therapy Weekly (2011-01-13)

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