Gene Therapy

Researchers from Veterans Affairs Medical Center publish findings in gene therapy

Published in Gene Therapy Weekly, January 13th, 2011

2011 JAN 13 -- Current study results from the report, 'Wherefore art thou, YY1,' have been published. According to recent research published in the Journal of Investigative Dermatology, "In this issue, Taguchi et al. demonstrate that the transcription factor Yin Yang-1 (YY1) regulates proliferation in three-dimensional cultures of the HaCaT human keratinocyte cell line."

"HaCaT keratinocytes overexpressing YY1 form artificial epidermal constructs that are thicker than those produced from vector-transfected cells. RNA interference-mediated YY1 knockdown decreases the thickness of YY1-overexpressing constructs, indicating that YY1 mediates the...

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Source: Gene Therapy Weekly (2011-01-13)

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