Gene Therapy

Findings from A.E. Carnes and co-authors provide new insights into gene therapy

Published in Gene Therapy Weekly, January 13th, 2011

2011 JAN 13 -- According to recent research from the United States, "For safety considerations, regulatory agencies recommend the elimination of antibiotic resistance markers and non-essential sequences from plasmid DNA-based gene medicines. In the present study, we analyzed antibiotic-free (AF) vector design criteria impacting upon bacterial production and mammalian transgene expression."

"Both CMV-HTLV-I R RNA Pol II promoter (protein transgene) and murine U6 RNA Pol III promoter (RNA transgene) vector designs were studied. Plasmid production yield was assessed through inducible fed-batch fermentation. RNA Pol II-directed enhanced green fluorescent...

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Source: Gene Therapy Weekly (2011-01-13)

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