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Reports Summarize Gene Therapy Study Results from University of Missouri

Published in Gene Therapy Weekly, January 20th, 2011

2011 JAN 20 -- A new study, 'Evidence for the failure of adeno-associated virus serotype 5 to package a viral genome > or = 8.2 kb,' is now available. "Limited packaging capacity hinders adeno-associated virus (AAV) gene therapy. A recent study seems to have provided a solution to this problem. Allocca et al. reported that AAV-5 could package an 8.9 kb vector genome," scientists in the United States report.

"Here we tested whether this approach can be used to deliver a large genome for Duchenne muscular dystrophy (DMD) gene therapy. We first evaluated AAV-5 packaging of an 8.2 kb genome. This vector carries two independent reporter gene cassettes, one...

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