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Gene Therapy

Research in the Area of Gene Therapy Reported from University of Pennsylvania

Published in Gene Therapy Weekly, January 27th, 2011

2011 JAN 27 -- "Redirecting T lymphocyte antigen specificity by gene transfer can provide large numbers of tumor-reactive T lymphocytes for adoptive immunotherapy. However, safety concerns associated with viral vector production have limited clinical application of T cells expressing chimeric antigen receptors (CAR)," researchers in the United States report.

"T lymphocytes can be gene modified by RNA electroporation without integration-associated safety concerns. To establish a safe platform for adoptive immunotherapy, we first optimized the vector backbone for RNA in vitro transcription to achieve high-level transgene expression. CAR expression and...

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