Gene Therapy

Research from University of Auckland in the Area of Gene Therapy Published

Published in Gene Therapy Weekly, February 3rd, 2011

2011 FEB 3 -- According to recent research from Auckland, New Zealand, "Dendritic cells are the key antigen-presenting cells involved in the initiation of the adaptive immune response. Recombinant adeno-associated viruses (rAAVs) can transduce dendritic cells and have gained attention as potential vaccines capable of stimulating T cell immunity."

"Here we show that rAAV2 pseudotyped with type 6 capsid (rAAV2/6) exhibits significantly higher tropism for human monocyte-derived dendritic cells (MoDCs) than other serotypes and variants. Transduction was abolished by a single lysine-to-alanine mutation within the AAV6 capsid previously shown to inhibit binding...

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Source: Gene Therapy Weekly (2011-02-03)

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