Transcription Factors

Reports from Johns Hopkins University, Medical Department Advance Knowledge in Transcription Factors

Published in Gene Therapy Weekly, February 3rd, 2011

2011 FEB 3 -- According to a study from the United States, "Delta Np63 alpha, the dominant negative isoform of the p63 family is an essential survival factor in head and neck squamous cell carcinoma. This isoform has been shown to be downregulated in response to several DNA damaging agents, thereby enabling an effective cellular response to genotoxic agents."

"Here, we identify a key molecular mechanism underlying the regulation of Delta Np63 alpha expression in response to extrinsic stimuli, such as chemotherapeutic agents. We show that Delta Np63 alpha interacts with NF kappa B in presence of cisplatin. We find that NF kappa B promotes ubiquitin-mediated...

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Source: Gene Therapy Weekly (2011-02-03)

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