Gene Therapy
Studies from Gifu University, Division of Cardiology Add New Findings in the Area of Gene Therapy
Published in Gene Therapy Weekly, February 17th, 2011
2011 FEB 17 -- New research, 'Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis,' is the subject of a report. According to recent research from Gifu, Japan, "Activation of Fas signaling is a key mediator of doxorubicin cardiotoxicity, which involves both cardiomyocyte apoptosis and myocardial inflammation. In this study, acute cardiotoxicity was induced in mice by doxorubicin, and some mice simultaneously received an intramuscular injection of adenoviral vector encoding mouse soluble Fas (sFas) gene (Ad.CAG-sFas), an inhibitor of Fas/Fas ligand interaction."
"Two weeks later, left ventricular...
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Source: Gene Therapy Weekly (2011-02-17)
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