Gene Therapy

Research from University of Iowa, Department of Radiation Oncology in the Area of Gene Therapy Published

Published in Gene Therapy Weekly, February 24th, 2011

2011 FEB 24 -- Researchers detail in 'Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer,' new data in Gene Therapy. According to a study from the United States, "K-ras mutations occur in as high as 95% of patients with pancreatic cancer. K-ras activates Rac1-dependent NADPH oxidase, a key source of superoxide."

"Superoxide has an important function in pancreatic cancer cell proliferation, and scavenging or decreasing the levels of superoxide inhibits pancreatic cancer cell growth both in vitro and in vivo. DNA microarray analysis and RT-PCR has demonstrated that Rac1 is also upregulated in pancreatic cancer. The aim of this study was...

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Source: Gene Therapy Weekly (2011-02-24)

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