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Heart Disease

Just in time for Valentine's Day: UNC researchers identify a gene critical for heart function

Published in Gene Therapy Weekly, February 24th, 2011

2011 FEB 24 -- CHAPEL HILL, N.C. - Everyone knows chocolate is critical to a happy Valentine's Day. Now scientists are one step closer to knowing what makes a heart happy the rest of the year.

It's a gene called DOT1L, and if you don't have enough of the DOT1L enzyme, you could be at risk for some types of heart disease. These findings from a study led by researchers at the University of North Carolina at Chapel Hill School of Medicine appear in the Feb. 1, 2011 issue of the journal Genes and Development.

The team created a special line of mice that were genetically predisposed to dilated cardiomyopathy, a condition in which the heart...

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