Science
Reports from Wellcome Trust Sanger Institute Highlight Recent Research in Science
Published in Gene Therapy Weekly, March 10th, 2011
2011 MAR 10 -- Researchers detail in 'A hyperactive piggyBac transposase for mammalian applications,' new data in Science. According to a study from Cambridge, the United Kingdom, "DNA transposons have been widely used for transgenesis and insertional mutagenesis in various organisms. Among the transposons active in mammalian cells, the moth-derived transposon piggyBac is most promising with its highly efficient transposition, large cargo capacity, and precise repair of the donor site."
"Here we report the generation of a hyperactive piggyBac transposase. The active transposition of piggyBac in multiple organisms allowed us to screen a transposase mutant...
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Source: Gene Therapy Weekly (2011-03-10)
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