Studies Conducted at University of California, Division of Pulmonary on Gene Therapy Recently Published

2011 MAR 10 -- Fresh data on Gene Therapy are presented in the report 'Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation.' "Humanized mouse models provide a unique opportunity to study human immune cells in vivo, but traditional models have been limited to the evaluation of non-specific T-cell interactions due to the absence of antigen-presenting cells. In this study, immunodeficient NOD/SCID/IL2r-'(null) (NSG) mice were engrafted with human peripheral blood lymphocytes alone or in combination with donor-matched monocyte-derived dendritic cells (DC) to determine whether antigen-specific T-cell activation could be...

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