Small Interference RNAs (siRNAs)
New Research on Small Interference RNAs (siRNAs) from University of Pais Vasco Summarized
Published in Gene Therapy Weekly, March 24th, 2011
2011 MAR 24 -- Current study results from the report, 'Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP,' have been published. According to recent research from Zamudio, Spain, "Interleukin-12 (IL-12), p80, and IL-23 are structurally related cytokines sharing a p40 subunit. We have recently demonstrated that celecoxib and its COX-2-independent analogue 4-trifluoromethyl-celecoxib (TFM-C) inhibit secretion but not transcription of IL-12 (p35/p40) and p80 (p40/p40)."
"This is associated with a mechanism involving altered...
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Source: Gene Therapy Weekly (2011-03-24)
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