Thyroid Disease

Researchers from King's College London Describe Findings in Thyroid Disease

Published in Gene Therapy Weekly, April 7th, 2011

2011 APR 7 -- "Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy. There is no readily available positron emission tomography (PET) tracer for hNIS," scientists writing in the journal Nuclear Medicine Communications report.

"Our aim was to develop a colon carcinoma cell line stably expressing hNIS, and use it to evaluate a novel hNIS PET tracer, [F-18]-tetrafluoroborate. Colon carcinoma cell line, HCT116, was stably transfected with hNIS, thus producing a cell line, HCT116-C19, with high hNIS...

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Source: Gene Therapy Weekly (2011-04-07)

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