Lentivirus Infections
Studies from State University of New York Reveal New Findings on Lentivirus Infections
Published in Gene Therapy Weekly, April 7th, 2011
2011 APR 7 -- Research findings, 'JNK1 is required for lentivirus entry and gene transfer,' are discussed in a new report. According to recent research published in the Journal of Virology, "Although a lot of progress has been made in development of lentiviral vectors for gene therapy, the interactions of these vectors with cellular factors have not been explored adequately. Here we show that lentivirus infection phosphorylates JNK and that blocking the kinase activity of JNK decreases gene transfer in a dose-dependent manner, regardless of the viral envelope glycoprotein."
"Knockdown by small interfering RNA (siRNA) revealed that JNK1 but not JNK2...
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Source: Gene Therapy Weekly (2011-04-07)
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