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Whooping Cough

New Whooping Cough Research Reported from University of Maryland

Published in Gene Therapy Weekly, April 28th, 2011

2011 APR 28 -- "Wang WC, Schillinger RM, Malone MM, Liggett SB. Paradoxical attenuation of beta(2)-AR function in airway smooth muscle by G(i)-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase," investigators in Baltimore, United States report.

"Am J Physiol Lung Cell Mol Physiol 300: L472-L478, 2011. First published December 3, 2010; doi:10.1152/ajplung.00273.2010.-The limiting component within the receptor-G protein-effector complex in airway smooth muscle (ASM) for beta(2)-adrenergic receptor (beta(2)-AR)-mediated relaxation is unknown. In cardiomyocytes, adenylyl cyclase (AC) is considered the ''bottleneck'' for...

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