Cancer Vaccines

Research in the Area of Cancer Vaccines Reported from Nanjing Medical University

Published in Gene Therapy Weekly, May 5th, 2011

2011 MAY 5 -- According to recent research from Nanjing, People's Republic of China, "Costimulatory signals are essential for T-cell activation and hence play a very important role in antitumor immunity. B7 and 4-1BBL which belongs to tumor necrosis factor (TNF) family provide costimulatory interaction for T-cell activation and function."

"This study investigated the role of B7 and 4-1BBL in the amplification of tumor immunity by transduction of the B7-1, B7-2 and 4-1BBL into mouse hepatocellular carcinoma cell line H22. The tumorigenicity of H22 variants expressing either B7-1, B7-2 (H22/B7-1/B7-2) or 4-1BBL was compared with an H22 variant expressing...

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Source: Gene Therapy Weekly (2011-05-05)

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