Gene Therapy
Studies from H. Zhong et al Have Provided New Data on Gene Therapy
Published in Gene Therapy Weekly, May 5th, 2011
2011 MAY 5 -- According to recent research from Beijing, People's Republic of China, "Chitosan, a cationic polysaccharide, can enhance recombinant adenovirus vector (rAdv)-mediated gene transduction (AMGT) in cells that lack the rAdv receptor, coxsackie-adenovirus receptor (CAR). However, gene transduction using chitosan for such cell types has so far only been successful under non-physiological pH conditions as chitosan is insoluble under physiological pH conditions."
"Here we report that NaHCO3 can greatly improve the solubility of chitosan at physiological pH (pH 7.4). We show that this chitosan/NaHCO3 solution increases AMGT approximately 8-24-fold in...
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Source: Gene Therapy Weekly (2011-05-05)
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