Cardiology

Study Data from I. Pinz and Co-Authors Update Knowledge of Cardiology

Published in Gene Therapy Weekly, May 12th, 2011

2011 MAY 12 -- According to recent research from Scarborough, United States, "The sarcoplasmic reticulum calcium ATPase (SERCA) plays a central role in regulating intracellular Ca2+ homeostasis and myocardial contractility. Several studies show that improving Ca2+ handling in hypertrophied rodent hearts by increasing SERCA activity results in enhanced contractile function."

"This suggests that SERCA is a potential target for gene therapy in cardiac hypertrophy and failure. However, it raises the issue of increased energy cost resulting from a higher ATPase activity. In this study, we determined whether SERCA overexpression alters the energy cost of...

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Source: Gene Therapy Weekly (2011-05-12)

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