Pennsylvania State University Publishes Research in Colloids and Interface Science

2011 MAY 26 -- A new study, "Separation of plasmid DNA isoforms by highly converging flow through small membrane pores," is now available. According to recent research published in the Journal of Colloid and Interface Science, "Plasmid DNA isoforms can be separated by both agarose gel electrophoresis and a variety of chromatographic methods, but both of these approaches have significant shortcomings in terms of scalability, throughput, and/or resolution. This study provides the first demonstration that the supercoiled, linear, and open-circular isoforms of plasmid DNA can be effectively separated based on differences in their elongational flexibility in the highly...

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