Gliomas

Studies from Ajou University in the Area of Gliomas Described

Published in Gene Therapy Weekly, June 9th, 2011

2011 JUN 9 -- "Amiodarone is a widely used anti-arrhythmic drug that inhibits diverse ion channels, including the Na+/Ca2+ exchanger (NCX), L-type Ca2+ channels, and Na+ channels. Here, we report that subtoxic doses of amiodarone and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induced apoptosis of various glioma cells," investigators in Suwon, South Korea report.

"Treatment of U251MG glioma cells with amiodarone increased intracellular Ca2+ levels and enhanced the expression of the endoplasmic reticulum (ER) stress-inducible transcription factor C/EBP homologous protein (CHOP). This upregulation of CHOP was followed by...

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Source: Gene Therapy Weekly (2011-06-09)

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