Gene Therapy
Researchers at National Cancer Institute Target Gene Therapy
Published in Gene Therapy Weekly, June 16th, 2011
2011 JUN 16 -- According to a study from Bethesda, United States, "T-cell receptor (TCR) gene therapy enables for the rapid creation of antigen-specific T cells from mice of any strain and represents a valuable tool for preclinical immunotherapy studies. Here, we describe the superiority of gamma-retroviral vectors compared with lentiviral vectors for transduction of murine T cells and surprisingly illustrate robust gene-transfer into phenotypically naive/memory-stem cell like (TN/TSCM; CD62L(hi)/CD44(low)) and central memory (TCM; CD62L(hi)/CD44(hi)) CD8(+) T cells using murine stem cell-based g-retroviral vectors (MSGV1)."
"We created MSGV1 vectors for a...
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Source: Gene Therapy Weekly (2011-06-16)
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