Gene Therapy

Research from Kyushu University Provides New Data on Gene Therapy

Published in Gene Therapy Weekly, June 23rd, 2011

2011 JUN 23 -- According to a study from Fukuoka, Japan, "Lentiviral vectors are promising tools for the treatment of chronic retinal diseases including glaucoma, as they enable stable transgene expression. We examined whether simian immunodeficiency virus (SIV)-based lentiviral vector-mediated retinal gene transfer of human pigment epithelium-derived factor (hPEDF) can rescue rat retinal ganglion cell injury."

"Gene transfer was achieved through subretinal injection of an SIV vector expressing human PEDF (SIV-hPEDF) into the eyes of 4-week-old Wistar rats. Two weeks after gene transfer, retinal ganglion cells were damaged by transient ocular hypertension...

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Source: Gene Therapy Weekly (2011-06-23)

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