Gene Therapy

Study Data from Affiliated Hospital Provide New Insights into Gene Therapy

Published in Gene Therapy Weekly, July 14th, 2011

2011 JUL 14 -- "The genesis and development of hepatocellular carcinoma (HCC) is related to the abnormity of signaling pathway, telomerase, cell cycle, apoptosis, angiogenesis, and others, in which STAT3 signaling pathway plays a key role. The HCC cell line HepG(2) was transfected with small interfering RNA (siRNA) directed against STAT3," scientists writing in the journal Neoplasma report.

"After 72 h, cell growth and cycle were analysed by MTT and Flow cytometry. Then, the protein was extracted and the protein expression of STAT3, Smad3, p44/42, TERT, caspase-3, XIAP, Grp-78, HSP-27, MMP-2, MMP-9, VEGF-A, cyclin A, and cyclin E was detected by...

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Source: Gene Therapy Weekly (2011-07-14)

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