Colon Cancer
Studies from Vanderbilt University Yield New Information about Colon Cancer
Published in Gene Therapy Weekly, July 14th, 2011
2011 JUL 14 -- According to the authors of recent research from Nashville, United States, "E-cadherin is a transmembrane protein that maintains intercellular contacts and cell polarity in epithelial tissue. The down-regulation of E-cadherin contributes to the induction of the epithelial-to-mesenchymal transition (EMT), resulting in an increased potential for cellular invasion of surrounding tissues and entry into the bloodstream."
"Loss of E-cadherin has been observed in a variety of human tumors as a result of somatic mutations, chromosomal deletions, silencing of the CDH1 gene promoter, and proteolytic cleavage. To date, no compounds directly targeting...
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Source: Gene Therapy Weekly (2011-07-14)
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