Gene Therapy

Scientists at Osaka University Publish Research in Gene Therapy

Published in Gene Therapy Weekly, July 21st, 2011

2011 JUL 21 -- According to the authors of recent research from Osaka, Japan, "The efficient delivery of the hepatitis C virus (HCV) RNA subgenomic replicon into cells is useful for basic and pharmaceutical studies. The adenovirus (Ad) vector is a convenient and efficient tool for the transduction of foreign genes into cells in vitro and in vivo."

"However, an Ad vector expressing the HCV replicon has never been developed. In the present study, we developed Ad vector containing an RNA polymerase (pol) I-dependent expression cassette and a tetracycline-controllable RNA pol I-dependent expression system. We prepared a hybrid promoter from the...

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Source: Gene Therapy Weekly (2011-07-21)

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