Gene Therapy
Research from University of California Broadens Understanding of Gene Therapy
Published in Gene Therapy Weekly, August 11th, 2011
2011 AUG 11 -- Researchers detail in "Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins," new data in Gene Therapy. "Redirecting the tropism of viral vectors enables specific transduction of selected cells by direct administration of vectors. We previously developed targeting lentiviral vectors by pseudotyping with modified Sindbis virus envelope proteins," scientists in Los Angeles, California report.
"These modified Sindbis virus envelope proteins have mutations in their original receptor-binding regions to eliminate their natural tropisms, and they...
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Source: Gene Therapy Weekly (2011-08-11)
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