Colon Cancer

New Findings Reported from University of Navarra Describe Advances in Colon Cancer

Published in Gene Therapy Weekly, August 11th, 2011

2011 AUG 11 -- "To investigate whether single nucleotide polymorphisms (SNPs) in gemcitabine (GMB) metabolism genes were associated with clinical outcome in pre-treated metastatic colorectal cancer (mCRC) patients. SNPs of hCNT1, hENT1, CDA, dCTD and RRM1 genes were evaluated in 95 mCRC patients and detected using TaqMan genotyping assays," researchers in Pamplona, Spain report.

"Association of genotypes with overall response rate (ORR), time to progression (TTP) and overall survival (OS) was tested by univariate and multivariate analysis. RRM1 -37A > C polymorphism was correlated with GMB IC50 value and with the RRM1 gene expression level in CRC cell...

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Source: Gene Therapy Weekly (2011-08-11)

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