Breast Cancer

Studies from University of Texas Provide New Data on Breast Cancer

Published in Gene Therapy Weekly, August 18th, 2011

2011 AUG 18 -- "Successful treatment of p53 mutant, triple-negative breast cancers (TNBC) remains a daunting challenge. Doxorubicin (DOXO) and cisplatin (CDDP) are standard-of-care treatments for TNBC, but eventually fail due to acquired drug resistance and toxicity," researchers in Austin, Texas report.

"New treatments for overcoming drug resistance and toxicity in p53 mutant, TNBC are therefore badly needed. Unlike p53, p73 - a member of the p53 family - is usually not mutated in cancers and has been shown to regulate p53-mediated apoptotic signaling in p53-deficient cancers. Therefore, identification of anticancer agents that can activate p73 in...

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Source: Gene Therapy Weekly (2011-08-18)

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