Apoptosis

University of Chicago Reports Research in Apoptosis

Published in Gene Therapy Weekly, August 18th, 2011

2011 AUG 18 -- "In response to ultraviolet B damage, keratinocytes undergo apoptosis to eliminate damaged cells, thereby preventing tumorigenic transformation. Caffeine, the most widely consumed psychoactive substance, produces complex pharmacological actions; it has been shown to be chemopreventive in non-melamona skin cancer in mice through increasing apoptosis," researchers in Chicago, Illinois report.

"Here we have investigated the molecular and cellular mechanisms in the pro-apoptotic effect of caffeine on UVB-irradiated human HaCaT keratinocytes. Pretreatment with caffeine increased UVB-induced apoptosis in HaCaT cells. Caffeine blocked UVB-induced...

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Source: Gene Therapy Weekly (2011-08-18)

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